Abstract A106: Serum testosterone concentrations and risk of testicular germ cell tumors

A106 Although the incidence of testicular germ cell tumors (TGCT) has been rising worldwide, little known about the etiology. There is evidence, however, that TGCT is related to other male reproductive disorders, specifically, hypospadias, cryptorchidism and infertility. Because testosterone is responsible for the development and proliferation of testicular cells and testicular descent, it is plausible that testosterone and its binding protein, sex hormone binding globulin (SHBG), may be associated with TGCT risk. Using 512 case and 789 control participants from the U.S. Servicemen’s Testicular Tumor Environmental and Endocrine Determinants (STEED) Study, we assessed associations of pre-diagnostic serum SHBG and testosterone (measured total and calculated free) concentrations and risk of TGCT. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted logistic regression models. Among the controls, SHBG concentrations increased with age (p Citation Information: Cancer Prev Res 2008;1(7 Suppl):A106.