235 RIP3 Deficiency Enhances High Fat Diet-Induced Liver Injury and Hepatocyte Apoptosis in Mice

GDNF suppresses expression of genes associated with hepatic steatosisReal-time PCR analyses of gene expression in liver from WT and GDNF Tg mice maintained on RD or HFD for 12 weeks.Plotted are means + SEM.*, P<0.5; **, P<0.01; ***, P<0.001, relative to WT mice maintained on the RD.†, P<0.05; ‡, P<0.01; §, P<0.001, relative to GDNF Tg mice maintained on the HFD.n > 5 mice per group.GDNF enhances liver miR-122 and miR-107 levels miR-122 (A) and miR-107 (B) levels in liver from WT