Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation.

Olga A Morozova,Sharad Gupta,David W Colby

FEBS Letters（2015）

引用 15|浏览11

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摘要

•Conformational selection of misfolded HTT by immunopurification complements amyloidogenicity assays.•A11-reactive prefibrillar huntingtin oligomers are on the amyloid formation pathway.•A11-reactive prefibrillar huntingtin oligomers are stable in 6M guanidine.

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关键词

Oligomer,Amyloid,Protein misfolding,Neurodegeneration,Polyglutamine,Huntington’s disease

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