UP-01.174 Methylenetetrahydrofolate Reductase Genotype and Haplotype May Be Associated with the Aggressiveness and Prognosis of Clear Cell Renal Cell Carcinoma

There are two common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, which both have been reported to cause decreased enzyme activity. This decreased in activity reduces the quantity of methyl groups available for DNA methylation, and leads to misincorporation of uracil into DNA, resulting in single strand DNA breaks. These effects might induce the accumulation of multiple genetic changes, leading to the development and progression of clear cell renal cell carcinoma (CCRCC). Thus, MTHFR polymorphisms may have the potential to impact on tumor aggressiveness or prognosis of CCRCC. We investigated the associations between MTHFR genotypes and haplotypes and clinicopathological characteristics and survival rates in Japanese patients with CCRCC to determine their predictive value for the clinical course of CCRCC.