FOX03A DEFICIENCY PROTECTS FROM COXSACKIEVIRUS B3 MYOCARDITIS: ROLE OF NK CELL FUNCTION

Luise Holzhauser,Madlen Loebel,Alexander Jenke, Moritz Becher,Sandra Bauer,Sandra Pinkert,Henry Fechner,Wolfgang Poller,Heinz-Peter Schultheiss,Carmen Scheibenbogen,Carsten Skurk

Journal of the American College of Cardiology（2015）

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摘要

Coxsackievirus B3 (CVB3) myocarditis can lead to dilative cardiomyopathy and heart failure. Cardiac injury is mediated by direct viral damage and host immune response. FOXO transcription factors play key roles in immunoregulation and stress resistance, including anti-inflammatory effects. We

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