IMPACT OF MORPHINE ON PHARMACOKINETIC AND PHARMACODYNAMIC PROFILES OF TICAGRELOR IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

Dominick J Angiolillo,Theodore A Bass,Luis A Guzman,Martin M Zenni,Siva Suryadevara, Edward Carraway,Amit Nanavati,Elizabeth C Dunn,Elisabetta Ferrante,Christopher Degroat,Mona Bhatti,Jung Rae Cho,Fabiana Rollini,Francesco Franchi

Journal of the American College of Cardiology（2015）

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摘要

In patients undergoing primary percutaneous coronary intervention (PPCI), morphine delays the pharmacodynamic (PD) effects of P2Y12 inhibitors, including prasugrel and ticagrelor. However, to date studies with novel P2Y12 inhibitors have been limited to PD assessments. The impact of morphine on

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