A RANDOMIZED, ACTIVE- AND PLACEBO-CONTROLLED, THREE-PERIOD CROSSOVER TRIAL TO INVESTIGATE SHORT-TERM EFFECTS OF THE DIPEPTIDYL PEPTIDASE-4 INHIBITOR LINAGLIPTIN ON ENDOTHELIAL FUNCTION IN TYPE 2 DIABETES

Alin Stirban, Arne Terjung, Habib Esmaeili,Andreas Berk,Sandra Thiemann,Robert Chilton,Nikolaus Marx,Maximilian Von Eynatten,Thomas W Jax

Journal of the American College of Cardiology（2015）

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摘要

Studies of dipeptidyl peptidase-4 inhibitors (DPP-4i) report heterogeneous effects on endothelial function in patients with type 2 diabetes. This study assessed the effects of the DPP-4i linagliptin (LINA) vs the sulfonylurea glimepiride (GLIM) and placebo (PBO) on measures of macro- and

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