GW25-e5316 Resveratrol supplementation was not beneficial to the anti-inflammatory effects and metabolic modulation in the prevention of cardiovascular disease and stable coronary artery disease: A meta-analysis

synthase ( iNOS ) was determined using iNOS assay kit. Results: In the early group, the relaxation response to ACh was increased significantly in HRT group than that in ovariectomized model group, while there was no difference in the relaxation response to ACh between HRT group and ovariectomized model group in the late group. And there were no difference in the relaxation response to SNP between HRT group and ovariectomized model group in the early group and the late group; In the early group, transmission electron microscopy images of aorta in HRT group presented no swelling of endothelial cells, no vacuoles in tracytoplasmic, successive internal elastic lamina, endothelial cells attachment to elastic plate closely and regularly arranged smooth muscle cells compared to that in ovariectomized early group. However, there was no difference in transmission electron microscopy images between HRT group and ovariectomized model group in the late group; In the early group, the serum level of NO increased markedly in HRT group compared to the ovariectomized model group. In the late group, the serum level of NO in HRT group was similar to ovariectomized model group; There were no obvious changes in aortic iNOS content between HRT group and ovariectomized model group in the early group as well as in the late group. Conclusions: HRT improved endothelial destruction and endothelial-dependent vasodilation in the early HRT model, which related to nitric oxide release from endothelial cells. Aortic iNOS content didn’t increased with the extension of ovariectomized time, and didn’t increased by HRT in the early group as well as in the late group.