Inhibitory actions of bisabolol on α7-nicotinic acetylcholine receptors

•Bisabolol is a naturally occurring monocyclic sesquiterpene alcohol with anti-nociceptive and anti-inflammatory actions.•Bisabolol reversibly and concentration dependently inhibits ACh-induced α7 receptor-mediated currents.•The effect of bisabolol was noncompetitive, not dependent on the membrane potential or intracellular Ca2+ levels.•Choline-induced currents in rat hippocampal neurons were also inhibited by bisabolol.