Abstract 2974: Epigenetic silencing DACH1 activated both TGF-β and Wnt signaling in colorectal cancer.

Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western countries. The incidence of CRC is increasing very fast with the changing of diet and life style in China. Both Wnt and TGF-β signaling pathways were regarded to play important roles in the development of colorectal cancer. Recent studies have found that the TGF-β and Wnt signaling pathways are crosstalking during breast cancer carcinogenesis and other situations. DACH1 was found inhibiting TGF-β signaling in breast and ovarian cancer. The epigenetic regulation and the function of DACH1 in colorectal cancer remain unclear. Objective To evaluate the possibility of DACH1 methylation serving as CRC detection marker and the regulation of DACH1 expression in colorectal cancer, the role of DACH1 in TGF-β W 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2974. doi:10.1158/1538-7445.AM2013-2974