Recombinant influenza virus carrying human adenovirus epitopes elicits protective immunity in mice

Penghui Yang,Tieling Li,Na Liu,Hongjing Gu,Lina Han,Peirui Zhang,Zhiwei Li,Zhaohai Wang,Shaogeng Zhang,Xiliang Wang

Antiviral Research（2015）

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摘要

•A recombinant influenza virus rFLU/HAdV containing HAdV hexon protein epitopes was produced.•rFLU/HAdV induced robust humoral, mucosal, and cell-mediated immune responses against HAdV in vivo.•rFLU/HAdV conferred protection against wild-type HAdV-3 or HAdV-7 challenge.•rFLU/HAdV warrants further investigation as a promising HAdV candidate vaccine.

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关键词

Influenza virus,HAdV,Hexon protein epitopes,Viral vector

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