Synthesis Of Co/Tio2 Nanocomposite And Its Use In Construction Of A Sensitive And Selective Sensor For Determination Of Ciprofloxacin

The Co/TiO2 nanocomposite was synthesized by a modified sol-gel method. The surface structure and composition of nanoparticles were characterized by scanning electron microscopy (SEM), X-ray powder diffraction analysis (XRD), Fourier transform infrared (FUR) spectrometry, thermal gravimetric analysis (TGA) and N-2 physisorption. A carbon paste electrode (CPE) modified with Co/TiO2 nanocomposite was prepared and used for low level determination of antibiotic ciprofloxacin (CF) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the modified electrode exhibited a linear response over the concentration range of 0.1 to 70 mu M CF, with a detection limit of 0.03 mu M. The proposed sensor was applied to the CF determination in serum and urine samples.