Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug

yaxin lu
yaxin lu
kang qin
kang qin
yingping tian
yingping tian
jingli hou
jingli hou

Journal of Controlled Release, pp. 179-188, 2015.

Cited by: 27|Views5

Abstract:

Nitric oxide (NO) is an important signaling molecule in cardiovascular system, and the sustained release of NO by endothelial cells plays a vital role in maintaining patency and homeostasis. In contrast, lack of endogenous NO in artificial blood vessel is believed to be the main cause of thrombus formation. In this study, enzyme prodrug t...More

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