Activation of IGF1R/p110β/AKT/mTOR Confers Resistance to Α-Specific PI3K Inhibition
Breast cancer research(2016)
摘要
The PI3K pathway is hyperactivated in many cancers, including 70 % of breast cancers. Pan- and isoform-specific inhibitors of the PI3K pathway are currently being evaluated in clinical trials. However, the clinical responses to PI3K inhibitors when used as single agents are not as efficient as expected.
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关键词
Phosphatidylinositol 3-kinase,p110α,p110β,Resistance,Breast cancer
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