One-step homozygosity in precise gene editing by an improved CRISPR/Cas9 system

Pei Zhao,Zhe Zhang,Xiaoying Lv,Xiang Zhao,Yuji Suehiro, Yinan Jiang,Xinquan Wang,Shohei Mitani,Haipeng Gong,Ding Xue

CELL RESEARCH（2016）

引用 13|浏览18

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摘要

The CRISPR/Cas9 gene editing method has been successfully applied to modify genomes in many organisms1. However, several critical issues remain unresolved and have become major hurdles for its broad applications1.

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关键词

CR,cancer,immunology,neurodegeneration,apoptosis,cell death,cell growth,differentiation

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