LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Jian Luo,Zhengfeng Yang,Yu Ma,Zhiying Yue, Hongyu Lin,Guojun Qu,Jinping Huang,Wentao Dai,Chenghai Li,Chunbing Zheng,Leqin Xu,Huaqing Chen,Jiqiu Wang,Dali Li,Stefan Siwko,Josef M Penninger,Guang Ning,Jianru Xiao,Mingyao Liu

NATURE MEDICINE（2016）

引用 268|浏览27

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摘要

LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mouse models of osteoporosis.

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关键词

G protein-coupled receptors,Central control of bone remodelling,Osteoporosis

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