Cardiac effect of vitamin D receptor modulators in uremic rats.

Masahide Mizobuchi,Hiroaki Ogata,Ai Yamazaki-Nakazawa,Nozomu Hosaka,Fumiko Kondo,Fumihiko Koiwa,Eriko Kinugasa,Takanori Shibata

The Journal of Steroid Biochemistry and Molecular Biology（2016）

引用 9|浏览8

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摘要

•A novel vitamin D receptor modulator VS-105 suppresses PTH in 5/6 nephrectomized rats with reduced hypercalcemic side effect compared with paricalcitol.•VS-105 is potent for cardioprotection through inhibition of cardiac remodeling.•The anti-fibrotic effect on the cardiac tissue is a distinct property of VS-105.

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关键词

Vitamin D receptor modulator,Vitamin D receptor,Cardiac remodeling,Fibrosis

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