Determination of a novel Aurora-A (AurA) kinase AKI603 by UPLC-MS/MS and its application to a bioavailability study in rat.

Zhenzhen Zhao, Lingjie Huang,Xiaoli Gou,Zhangwei Li,Jiangying Chen,Dingsheng Wen,Fulin Jiang,Gui Lu,Huichang Bi,Min Huang,Guoping Zhong

Journal of Pharmaceutical and Biomedical Analysis（2016）

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摘要

•A UPLC-MS/MS method for the determination of AKI603 in rat plasma has been firstly developed and validated.•The method has been used to the bioavailability study of AKI603 administered to rats.•The result suggests the potential for AKI603 developed as an orally administered drug.

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关键词

AKI603,UPLC-MS/MS,Method validation,Oral bioavailability study,Rat

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