The crystal structure of Cpf1 in complex with CRISPR RNA

De Dong,Kuan Ren,Xiaolin Qiu, Jianlin Zheng,Minghui Guo,Xiaoyu Guan,Hongnan Liu,Ningning Li,Bailing Zhang,Daijun Yang,Chuang Ma,Shuo Wang,Dan Wu, Yunfeng Ma,Shilong Fan,Jiawei Wang,Ning Gao,Zhiwei Huang

NATURE（2016）

引用 385|浏览31

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摘要

The crystal structure of monomeric Lachnospiraceae bacterium Cpf1 protein bound to CRISPR RNA is presented, establishing a framework for engineering LbCpf1 to improve its efficiency and specificity for genome editing.

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关键词

Bacterial structural biology,Genetic engineering,X-ray crystallography,RNA

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