IgM antibodies against malondialdehyde and phosphorylcholine are together strong protection markers for atherosclerosis in systemic lupus erythematosus: Regulation and underlying mechanisms.

•IgM antibodies against phosphorylcholine (PC) and malondialdehyde (MDA) are together striking protection markers for vulnerable plaque in SLE•Unexpectedly, these natural antibodies are T cell dependent•Uptake of apoptotic cells was increased by anti-PC and anti-MDA.•MDA induced increased oxidative stress, which was inhibited by anti-MDA