Tissue-infiltrating plasma cells are an important source of carboxylesterase 2 contributing to the therapeutic efficacy of prodrugs.

Anja A Kühl,Ulrike Erben,Constanze Cieluch,Simone Spieckermann,Jörn Gröne,Philipp Lohneis,Ulrich Frank Pape,Ruza Arsenic,Nalân Utku

Cancer Letters（2016）

引用 7|浏览3

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摘要

•CES-2 protein levels in colorectal cancer in situ are not related to tumor grade.•CES-2high plasma cells are found in intestinal tissue of cancer and inflammation.•In hepatocytes, CES-2 expression declines during tumorigenesis.•Peripheral blood mononuclear cells of healthy donors express low levels of CES-2.

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关键词

Colorectal cancer,Tumors,Inflammatory bowel disease,Immunohistochemistry,Plasma cells

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