Unique human immune signature of Ebola virus disease in Guinea

Paula Ruibal,Lisa Oestereich,Anja Lüdtke,Beate Becker-Ziaja,David M. Wozniak,Romy Kerber,Miša Korva,Mar Cabeza-Cabrerizo,Joseph A. Bore,Fara Raymond Koundouno,Sophie Duraffour,Romy Weller,Anja Thorenz,Eleonora Cimini,Domenico Viola,Chiara Agrati,Johanna Repits,Babak Afrough,Lauren A. Cowley,Didier Ngabo,Julia Hinzmann,Marc Mertens,Inês Vitoriano,Christopher H. Logue, Jan Peter Boettcher,Elisa Pallasch,Andreas Sachse,Amadou Bah, Katja Nitzsche,Eeva Kuisma,Janine Michel,Tobias Holm, Elsa-Gayle Zekeng,Isabel García-Dorival,Roman Wölfel,Kilian Stoecker,Erna Fleischmann,Thomas Strecker,Antonino Di Caro,Tatjana Avšič-Županc,Andreas Kurth,Silvia Meschi,Stephane Mély,Edmund Newman,Anne Bocquin,Zoltan Kis, Anne Kelterbaum, Peter Molkenthin,Fabrizio Carletti,Jasmine Portmann,Svenja Wolff,Concetta Castilletti,Gordian Schudt,Alexandra Fizet, Lisa J. Ottowell,Eva Herker,Thomas Jacobs,Birte Kretschmer,Ettore Severi,Nobila Ouedraogo,Mar Lago,Anabel Negredo,Leticia Franco,Pedro Anda,Stefan Schmiedel,Benno Kreuels,Dominic Wichmann,Marylyn M. Addo,Ansgar W. Lohse,Hilde De Clerck, Carolina Nanclares,Sylvie Jonckheere,Michel Van Herp,Armand Sprecher,Gao Xiaojiang,Mary Carrington,Osvaldo Miranda,Carlos M. Castro,Martin Gabriel,Patrick Drury,Pierre Formenty,Boubacar Diallo,Lamine Koivogui,N’Faly Magassouba,Miles W. Carroll,Stephan Günther,César Muñoz-Fontela

NATURE（2016）

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摘要

Fatal Ebola virus disease is characterized by a high proportion of CD4 + and CD8 + T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8 + T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.

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Viral infection,Ebola virus

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