Synthesis, molecular properties prediction and cytotoxic screening of 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones.

Angélica Faleiros da Silva Maia,Raoni Pais Siqueira,Fabrício Marques de Oliveira,Joana Gasperazzo Ferreira,Silma Francielle da Silva,Clarice Alves Dale Caiuby,Leandro Licursi de Oliveira,Sérgio Oliveira de Paula,Rafael Aparecido Carvalho Souza,Silvana Guilardi,Gustavo Costa Bressan,Róbson Ricardo Teixeira

Bioorganic & Medicinal Chemistry Letters（2016）

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摘要

•A series of nineteen 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones was prepared.•Isobenzofuranones were screened against HL-60, K562 and NALM6 cancer cell lines.•The most active compound 18 triggered early events of apoptosis on NALM6.•Compounds did no present cytotoxicity against PBMC cells.

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关键词

Isobenzofuran-1(3H)-one,Phthalides,3-(2-Aryl-2-oxoethyl)isobenzofuran-1(3H)-ones,Cytotoxicity

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