Inhibition of mammalian target of rapamycin activation in the rostral anterior cingulate cortex attenuates pain-related aversion in rats.

Bo Lu,Jingyan Jiang,Jianliang Sun,Chun Xiao,Bo Meng,Jinwei Zheng,Xiaoyu Li,Ruichun Wang,Guorong Wu,Junping Chen

Behavioural Brain Research（2016）

引用 10|浏览30

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摘要

•A nociceptive stimulus induced an upregulation of p-mTOR and p-p70S6K in the rACC.•Intra-rACC injection of rapamycin attenuated pain-related aversion.•Rapamycin infusion into the rAAC did not affect nociceptive behaviors.

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关键词

mTOR,p70S6k,ACC,rACC,F-CPA,CPP,AMPA,KA

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