Relationship between spontaneous γH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors.

Junko Kajimura,Seishi Kyoizumi,Yoshiko Kubo,Munechika Misumi,Kengo Yoshida,Tomonori Hayashi,Kazue Imai,Waka Ohishi,Kei Nakachi,Nan-Ping Weng,Lauren F Young,Jae-Hung Shieh,Malcolm A Moore,Marcel R M van den Brink,Yoichiro Kusunoki

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•Frequency of γH2AX foci in HSPCs was inversely associated with the length of granulocyte telomeres.•The γH2AX foci frequency was not significantly elevated by past radiation.•A negative interaction effect between the radiation dose and of the γH2AX foci frequency was suggested in the proportion of CAFC.•Effect of DNA damage on the self-renewability of HSPCs may be modified by A-bomb radiation exposure.

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关键词

Hematopoietic stem and progenitor cells,γH2AX,Telomere length,DNA damage,Atomic-bomb,Self-renewability

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