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Toll-like receptor 2 signalling: Significance in megakaryocyte development through wnt signalling cross-talk and cytokine induction.

Ram Babu Undi,Shilpa Sarvothaman,Kovuru Narasaiah,Usha Gutti,Ravi Kumar Gutti

Cytokine（2016）

Cited 21|Views3
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Abstract
•TLR2 induces megakaryocyte maturation and increase cytokine production.•TLR2 is involved in ROS production, which is essential for megakaryocyte maturation.•TLR2 induce wnt signalling suggesting a cross talk between wnt and TLR pathway.
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Key words
Megakaryocyte,TLR2,Wnt/β-catenin,IL-6,FZD4
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