Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains.

G Gimenez,M L Belaunzarán,K G Magalhães,C V Poncini, E M Lammel,S M González Cappa,P T Bozza, E L D Isola

Veterinary Parasitology（2016）

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摘要

•B. bovis lipids (LA and LV) promote lipid body formation in macrophages via TLR6.•TLR6 mediates down-modulation of COX-2/PGE2 and IL-10 induced only by LA.•LA&LV different composition may correlate with polar behaviour of B. bovis strains.

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WT,TLR6KO,LA,LV,COX-2,PGE2

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