Baicalin Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Adenosine A2a Receptor Related TGF-β1-induced ERK1/2 Signaling Pathway.
BMC pulmonary medicine(2016)
摘要
Baicalin has been reported to have anti-fibrosis effect; however, its mechanism still remains to be elucidated. Adenosine A2a receptor (A2aR) is a novel inflammation regulator, and transforming growth factor-β1 (TGF-β1)-induced extracellular signal regulated kinase1/2 (ERK1/2) signaling pathway plays an important role in idiopathic pulmonary fibrosis (IPF). This study was to explore the relationship of A2aR and TGF-β1-induced ERK1/2 in bleomycin (BLM)-induced pulmonary fibrosis in mice, and to investigate whether A2aR mediate the anti-fibrosis effect of Baicalin on BLM-induced pulmonary fibrosis.
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关键词
Pulmonary fibrosis,Baicalin,Adenosine A2a receptor,Transforming growth factor-β1,Extracellular signal regulated kinase1/2
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