Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
European Journal of Medicinal Chemistry(2017)
摘要
The involvement of histamine H4 receptor (H4R) in immune cells chemotaxis and mediator release makes it an attractive target for the treatment of inflammation disorders. A decade of medicinal chemistry efforts has led to several promising ligands, although the chemical structures described so far possesses a singular limited diversity.
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关键词
Histamine,Virtual screening,H4 receptor,Homology model,Docking,Drug discovery
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