Urine metabolomics of high-fat diet induced obesity using UHPLC-Q-TOF-MS.

Lihui Men,Zifeng Pi,Yuan Zhou,Mengying Wei,Yuanyuan Liu,Fengrui Song,Zhongying Liu

Journal of Pharmaceutical and Biomedical Analysis（2017）

引用 30|浏览6

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摘要

•A high-fat diet (HFD) induced obese model was developed on Sprague-Dawley rats.•UPLC-Q-TOF-MS based urine metabolomics was studied to understand obesity and obesity-related dysfunction.•Multivariate analysis was performed to differentiate biomarkers with high sensitivity and specificity.•The biomarkers were mainly involved in tryptophan metabolism, phenylalanine metabolism, gut microbiota metabolism and insulin resistance.

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关键词

UHPLC-Q-TOF-MS,High-fat diet,Obesity,Rat urine metabolomics

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