Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine
NATURE REVIEWS DRUG DISCOVERY(2016)
摘要
Genome-wide association studies (GWAS) provide an unbiased approach for the discovery of potential mechanisms and pathways that underlie human characteristics, diseases and drug responses. As common diseases are frequently associated with genetic variants that exert small effect sizes, GWAS have increasingly focused on large cohorts of patients. For example, a… Download references
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关键词
Genome-wide association studies,Pharmacogenomics
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