Regulation of autoantibody activity by the IL-23–T H 17 axis determines the onset of autoimmune disease

Nature Immunology（2016）

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摘要

Krönke and colleagues show that the cytokine IL-23 controls the glycosylation profile and inflammatory activity of autoantibodies through control of sialyltransferase activity in plasma cells mediated by the T H 17 subset of helper T cells.

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关键词

Antibodies,Autoimmunity,Rheumatoid arthritis,T-helper 17 cells,Biomedicine,general,Immunology,Infectious Diseases

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