MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Phillip Pymm,Patricia T Illing,Sri H Ramarathinam,Geraldine M O'Connor,Victoria A Hughes,Corinne Hitchen,David A Price,Bosco K Ho,Daniel W McVicar,Andrew G Brooks,Anthony W Purcell,Jamie Rossjohn,Julian P Vivian

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

Structural determination and analysis of HLA-I that presents an HIV-derived peptide to an NK cell receptor reveal that N-terminal extended epitope conformations contribute to immune recognition and mechanisms of HIV immune escape.

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Immunology,X-ray crystallography

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