The Use of Self-Reported Symptoms As a Proxy for Acute Organophosphate Poisoning after Exposure to Chlorpyrifos 50% Plus Cypermethrin 5% among Nepali Farmers: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Previous studies stating a high prevalence of occupational acute pesticide poisoning in developing countries have mainly relied on measurements of the rather non-specific self-reported acute pesticide poisoning symptoms. Only a few studies have measured the biomarker plasma cholinesterase (PchE) activity, in addition to the symptoms, when assessing occupational acute pesticide poisoning. This study evaluated self-reported symptoms as a proxy for acute organophosphate poisoning among Nepali farmers by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational acute organophosphate exposure.