ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

Masayuki Sakurai,Yusuke Shiromoto,Hiromitsu Ota,Chunzi Song,Andrew V Kossenkov,Jayamanna Wickramasinghe,Louise C Showe,Emmanuel Skordalakes,Hsin-Yao Tang,David W Speicher,Kazuko Nishikura

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

引用 110|浏览6

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摘要

In stressed cells, the ADAR1p110 isoform is phosphorylated and translocated from the nucleus to the cytoplasm, where it protects transcripts with 3′-UTR dsRNA structures from Staufen1-mediated decay, thus suppressing cellular apoptosis.

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关键词

RNA editing,Molecular biology

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