Cellular DEAD-box RNA helicase 18 (DDX18) promotes the PRRSV replication via interaction with virus nsp2 and nsp10.

Huan Jin,Lei Zhou,Xinna Ge,Han Zhang,Ruimin Zhang,Cong Wang,Li Wang,Zhibang Zhang,Hanchun Yang,Xin Guo

Virus Research（2017）

引用 21|浏览22

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摘要

•The RNA helicase DDX18 interacts with the nsp2 and nsp10 of PRRSV.•DDX18 enhances the replication of PRRSV in cell culture.•Nsp2 and nsp10 relocates DDX18 from nucleus to cytoplasm.•DDX18 play a pro-viral role via its interaction with nsp2 and nsp10.

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关键词

Porcine reproductive and respiratory syndrome virus (PRRSV),Nonstructural protein 2 (nsp2),Nonstructural protein 10 (nsp10),DEAD (Asp-Glu-Ala-Asp)-box RNA helicase 18 (DDX18),Interaction,Replication

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