Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer(2017)
摘要
Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicles). They are small vesicles with phospholipid membrane carrying proteins, DNA and different classes of RNAs and are heavily involved in intercellular communication acting as vectors of information to target cells. For the last decade, the interest in EV research has exponentially increased though thorough studies of their roles in various pathologies that was not previously possible due to technical limitations. This review focuses on research evaluating the role of EV production in gastrointestinal (GI) cancer development in conjunction with GI microbiota and inflammatory diseases. We also discuss recent studies on the promising role of EVs and their content as biomarkers for early diagnosis of GI cancers.
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关键词
AchE,Ago,AnV,APC,ARF6,bft,bMVs,BPD,CEA,CEC,CrD,CRC,DAPI,DHR,DMEM,ECM,EGFP,EpCAM,EVs,FFPE,FP,GI,GM1,GPC1,IBD,IEM,IFC,IL,KRAS,lnsRNAs,LSPR,MEK-ERK,MPs,MUC1,MVs,MVBs,OD,OMPs,PBS,PC,PCA,PCD,PDAC,PDGFR,PE,PI,PODO,qRT-PCR,RFP,RISC,SCID,SELN,SMLM,TEV,TNF-alpha,TF,YSPAN8,VEGF,VTEs
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