Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.
Bioorganic & Medicinal Chemistry Letters(2017)
摘要
A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity. This chemotype represents a stepping stone towards chemical probes to study the consequences of lipid metabolism modulation through non-redundant pathways.
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关键词
fatty acid,kinase domain
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