Targeted overexpression of cyclic AMP-dependent protein kinase subunit in Toxoplasma gondii promotes replication and virulence in host cells.

Hongchao Sun,Suhua Wang,Xianfeng Zhao,Chaoqun Yao,Haohan Zhuang,Yechuan Huang,Xueqiu Chen,Yi Yang,Aifang Du

Veterinary Parasitology（2017）

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摘要

•T. gondii PKAC (TgPKAC) overexpression strain (TgPKAC-OE) was constructed.•Inhibition of TgPKAC could cause autophagy of Toxoplasma gondii and then influence the replication of the parasite.•TgPKAC plays an important role in parasite virulence in vivo.•TgPKAC was mainly expressed in the cytoplasm of Vero cell.

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关键词

Toxoplasma gondii,Protein kinase catalytic subunit,Growth,Autophagy,Virulence,Subcellular localization

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