The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling.

Lucia Fischetti,Ziyun Zhong,Christopher L Pinder,John S Tregoning,Robin J Shattock

Cytokine（2017）

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摘要

•Comparison of cytokine responses to TLR ligands in human cells and tissue.•Synergy in responses when R848 (TLR7/8 ligand) and GLA (TLR4 ligand) combined.•Synergy was inhibited by blocking the MAP Kinases p38 and JNK.

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关键词

Adjuvant,TLR,Synergy,Mucosal,Cytokine

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