Widespread Brain Distribution and Activity Following I.c.v. Infusion of Anti‐β‐secretase (BACE1) in Nonhuman Primates

The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood–brain barrier. I.c.v. delivery is a promising route to the brain; however, it is unclear how efficiently antibodies delivered i.c.v. penetrate the cerebrospinal spinal fluid (CSF)‐brain barrier and distribute throughout the brain parenchyma.