Transgender Women Living with Hiv Frequently Take Antiretroviral Therapy And/Or Feminizing Hormone Therapy Differently Than Prescribed Due to Drug-Drug Interaction Concerns

Purpose: Both hormone therapy (HT) and antiretroviral therapy (ART) can be lifesaving for transgender women (TW) living with HIV, but each has side effects and potential drug-drug interactions (DDI). We assessed how concerns about HT-ART interactions affect treatment adherence.Methods: This study used a cross-sectional survey of TW (n = 87) in Los Angeles, CA.Results: Fifty-four percent were living with HIV; 64% used HT. Only 49% of TW living with HIV discussed ART-HT DDI with their provider; 40% reported not taking ART (12%), HT (12%), or both (16%) as directed due to DDI concerns.Conclusion: Imperfect HT/ART use and limited provider communication suggests a need for improved HT-ART integration.