Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

Carlos H Martinez, Sara X Li, Andrew J Hirzel,Valerie R Stolberg, Neil E Alexis,R Graham Barr, Eugene R Bleecker,Elizabeth E Carretta,Stephanie A Christenson, Christopher B Cooper,David J Couper, Claire M Doerschuk,MeiLan K Han, Nadia N Hansel,Annette T Hastie, Eric A Hoffman,Robert J Kaner, Fernando J Martinez,Deborah A Meyers, Wanda K O'Neal,Robert Paine, Nirupama Putcha,Stephen I Rennard, Prescott G Woodruff,Michelle Zeidler, Jeffrey L Curtis,Christine M Freeman

The Journal of allergy and clinical immunology（2017）

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摘要

Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.

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