Transcriptomic and epigenomic biomarkers of antidepressant response.

•Antidepressant treatment is associated with a high rate of poor response.•Our review highlights the challenges to develop biomarkers of antidepressant response.•Several mRNAs and micro-RNAs have been described as potential biomarkers but replications are needed.•DNA methylation and histone modifications are also a promising avenue to develop biomarkers.