Pre- and Post-Test Probabilities of Venous Thromboembolism and Diagnostic Accuracy of D-dimer, Estimated by European Clinicians Working in Emergency Departments.

In patients with suspected venous thromboembolism (VTE), it is recommended to estimate the pre-test probability of VTE, either by experience or by standardized scoring schemes (e.g. Wells or Geneva score), before performing a D-dimer test [1,2]. Patients with a low probability or unlikely VTE should have D-dimer performed, and if negative, VTE can be excluded, without further investigations, while if positive, the patient should be referred to radiologic imaging to confirm or exclude VTE [1,2]. Patients with a high pre-test probability or likely VTE should be referred directly to radiologic imaging without D-dimer testing.