Heteronanoparticles by Self-Assembly of Doxorubicin and Cyclopamine Conjugates.

Gaia Fumagalli,Barbara Stella, Ievrnia Pastushenko,Francesca Ricci,Michael S. Christodoulou,Giovanna Damia,Davide Mazza,Silvia Arpicco,Clelia Giannini,Lavinia Morosi,Franco Dosio,Panagiota A. Sotiropoulou,Daniele Passarella

ACS MEDICINAL CHEMISTRY LETTERS（2017）

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摘要

The preparation of heteronanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumor growth and toxicity of chemotherapy.

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关键词

Self-assembled-nanoparticles,cyclopamine,doxorubicin,drug toxicity,cancer

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