Liposomal-delivery of phosphodiesterase 5 inhibitors augments UT-15C-stimulated ATP release from human erythrocytes.

Elizabeth A Bowles,Dimitri Feys,Nuran Ercal,Randy S Sprague

Biochemistry and Biophysics Reports（2017）

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摘要

The use of liposomes to affect targeted delivery of pharmaceutical agents to specific sites may result in the reduction of side effects and an increase in drug efficacy. Since liposomes are delivered intravascularly, erythrocytes, which constitute almost half of the volume of blood, are ideal targets for liposomal drug delivery.

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关键词

ATP,PAH,PDE,cGMP,PGI2,cAMP,sGC,DMPC,ZAP,TAD,PSS,FSC,SSC

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