Enhanced CD8(+) cytolytic T cell responses in the peripheral circulation of patients with sarcoidosis and non-Löfgren's disease.

Venkata Ramanarao Parasa,Helena Forsslund, Tobias Enger,Daniel Lorenz,Susanna Kullberg,Anders Eklund,Magnus Sköld,Jan Wahlström,Johan Grunewald,Susanna Brighenti

Respiratory Medicine（2018）

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摘要

•Higher proportion of CD8+ CTLs in sarcoidosis patients compared to controls.•High expression of perforin and granzyme B in blood CTLs from sarcoidosis patients.•Enhanced CTL responses in peripheral blood compared to BAL in sarcoidosis patients.•Particularly high levels of cytolytic effectors in blood CTLs from non-LS patients.•Elevated CTL function in sarcoidosis patients, particularly in non-LS patients.

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关键词

Sarcoidosis,CD8+ cytolytic T cells,Perforin,Granzyme B,Granulysin

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