Development of a safe and scalable route towards a tau PET tracer precursor.

Bjoern Bartels,Philipp Cueni,Dieter Muri,Matthias Koerner

Bioorganic & Medicinal Chemistry（2018）

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摘要

A scalable 5-step synthesis of the diazacarbazole derivative 1 used as tau PET tracer precursor is reported. Key features of this synthesis include a Buchwald-Hartwig amination, a Pd catalyzed CH activation and a Suzuki-Miyaura cross-coupling.

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关键词

calcd,h,IPC,min,NFT,NSB,NT,r.t.

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