Protein and mRNA expressions of IL-6 and its key signaling factors under orthodontic forces in mice: An in-vivo study.

•There is enhanced expression of IL-6 and its key signaling factors gp130, STAT3, and SHP2 protein and mRNA in periodontal tissues when orthodontic forces were applied.•IL-6 and its downstream signaling pathways might be activated during orthodontic treatment.•The result might demonstrate a special role of IL-6 and its key signaling factors in alveolar bone modeling process.